Quantification of Cardiomyocyte Hypertrophy by Cardiac Magnetic Resonance: Implications on Early Cardiac Remodeling Running title: Coelho-Filho et al.; Cardiomyocyte hypertrophy by MRI
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چکیده
M Me Medi d ci ine ne e, , , St tat ate e Un Univ iver ersi s ty ty o of f Ca Camp mpin inas as ((UN UNIC IC ICAM MP) P)), , , Ca C mp mp mpin in nas as, , Br Braz a il il; ; 4 Ca Card rdio iova vasc scul u ar ar Institute, B Be e eth h h Is Isr rael el D Dea ea eaco cone e es s ss M M Me edic cal al Cen nt nte er, Ha H Harv rv rvar r rd d Me Me Medica al S S Sch ch ho oo ol, l B B Bos osto ton n n, M MA A A *c *c con on nt t trib b but ute ed ed e equ qu qua al ally ly ly Ad Addr dres ess s fo for r Co Corr rres espo pond nden ence ce: : Abstract: Background—Cardiomyocyte hypertrophy is a critical precursor to the development of heart
منابع مشابه
Quantification of cardiomyocyte hypertrophy by cardiac magnetic resonance: implications for early cardiac remodeling.
BACKGROUND Cardiomyocyte hypertrophy is a critical precursor to the development of heart failure. Methods to phenotype cellular hypertrophy noninvasively are limited. The goal was to validate a cardiac magnetic resonance-based approach for the combined assessment of extracellular matrix expansion and cardiomyocyte hypertrophy. METHODS AND RESULTS Two murine models of hypertension (n=18, with ...
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Background and Objective: In this study the effect of high intensity interval training on miR-29 expression that is expressed in the heart and in the regulation of physiological processes, including extracellular matrix and cardiac hypertrophy of healthy male rats were examined. Materials and Methods: 16 Wistar rats were divided into training (n=8) and control (n=8) groups. After one week of fa...
متن کاملCardiac Magnetic Resonance Assessment of Interstitial Myocardial Fibrosis and Cardiomyocyte Hypertrophy in Hypertensive Mice Treated With Spironolactone
BACKGROUND Nearly 50% of patients with heart failure (HF) have preserved LV ejection fraction, with interstitial fibrosis and cardiomyocyte hypertrophy as early manifestations of pressure overload. However, methods to assess both tissue characteristics dynamically and noninvasively with therapy are lacking. We measured the effects of mineralocorticoid receptor blockade on tissue phenotypes in L...
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Buckwheat rutin has been found to be able to inhibit angiotensin II (AngII) - induced hypertrophy in cultured neonatal rat cardiomyocytes, but the mechanism remains uncertain. In this study, myocardial hypertrophy model was made by adding AngII to the medium of cardiac myocytes of neonatal rats, meanwhile, different concentrations of buckwheat rutin were applied to observe their effects. Intrac...
متن کاملBuckwheat Rutin Inhibits AngII-induced Cardiomyocyte Hypertrophy via Blockade of CaN-dependent Signal Pathway
Buckwheat rutin has been found to be able to inhibit angiotensin II (AngII) - induced hypertrophy in cultured neonatal rat cardiomyocytes, but the mechanism remains uncertain. In this study, myocardial hypertrophy model was made by adding AngII to the medium of cardiac myocytes of neonatal rats, meanwhile, different concentrations of buckwheat rutin were applied to observe their effects. Intrac...
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تاریخ انتشار 2013